Molecular biology

Molecular biology

Contributors in Molecular biology

Molecular biology

The process by which some genes are rendered non-equivalent. The paternal or maternal allele is not expressed (allelic exclusion), or is expressed differently in different tissues. The phenomenon is ...

Isomorphous replacement

Biology; Biochemistry

An X-ray crystallographic technique to assist in solving structures from a diffraction pattern. One or more heavy-metal atoms are inserted in the crystal (replacement) without disturbing the ...

Heteroduplex

Biology; Biochemistry

A partially double-stranded polynucleotide in which one strand contains sequences not fully complementary to the opposite strand, e.g. mRNA, which contains no introns, annealed to the coding strand ...

Informational RNA (iRNA)

Biology; Biochemistry

Essentially, intronic sequences of hnRNA, for which an evolutionary function has been proposed: by a mechanism analogous to the SELEX procedure, and in the absence of any conservative selective ...

Nuclear receptor

Biology; Biochemistry

A nuclear protein that allows regulation of gene expression by a lipophilic effector molecule, such as a steroid or thyroid hormone, eicosanoid, retinoid or ecdysone. When the effector molecule is ...

Analytical ultracentrifugation

Biology; Biochemistry

A technique of very-high-speed centrifugation that sediments soluble macromolecules and characterises them according to their rate of sedimentation (sedimentation-velocity ultracentrifugation) or the ...

N-terminal

Biology; Biochemistry

In a polypeptide sequence, that unique residue which is connected to the linear sequence by its carboxy group, leaving it with a free amino group. In practice, the amino group of an N-terminal ...