6 Terms
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Molecular biology
Industry: Biology
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Molecular biology
Sequence-tagged connector (STC)
Biology; Biochemistry
An approximately 500 bp sequence at each end of a bacterial artificial chromosome (BAC). If the human genome is cleaved into 300000 fragments, of an average length of 150 kb, there would be 600000 ...
Rolling circle replication
Biology; Biochemistry
Mechanisms of DNA replication of small circular genomes, such as some viruses and plasmids, in which the template generates multiple tandem copies. One strand is nicked and serves as a primer for ...
Equilibrium sedimentation ultracentrifugation
Biology; Biochemistry
A technique for evaluation of the molecular mass of a polymer by determination of the extent of sedimentation at which the force exerted upon a macromolecule in a centrifuge is balanced by its ...
Rolling transcription
Biology; Biochemistry
The synthesis of RNA from a circular DNA template. Some circular DNAs, even without a promoter sequence and without assistance of a primer, may be transcribed to form concatenated circular RNA. If ...
Free energy
Biology; Biochemistry
The form of energy that is capable of doing work at constant pressure and temperature; a concept that bridges the requirement that energy (enthalpy plus potential energy) be conserved and that the ...
Branch site
Biology; Biochemistry
In RNA splicing, the site to which the 5'-guanylate at the end of an intron is joined to an adenylate residue within the intron through a 2',5'-phosphodiester bond to form a 'lariat' intermediate.
Tandem enzymes
Biology; Biochemistry
A pair of opposing enzymic activities that are resident in the same polypeptide chain, e.g. isocitrate dehydrogenase kinase and phosphatase; phosphofructokinase 2 and fructose bisphosphatase 2.
