Molecular biology

Molecular biology

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Molecular biology

Primer

Biology; Biochemistry

An RNA sequence hybridised to a DNA template whose elongation by a DNA polymerase constitutes DNA synthesis. A random primer is a mixture of polynucleotides with all four bases at each sequence ...

In enzymology, a compound, or even a macromolecule, that blocks the action of an enzyme by reversible attachment in such a way as to prevent binding by the substrate (competitive inhibition), or by ...

Complementarity-determining region (CDR)

Biology; Biochemistry

A polypeptide sequence of a variable domain of an immunoglobulin that is particularly responsible for its recognition by lymphocytes. These short sequences interrupt and loop out from the framework ...

Perfusion chromatography

Biology; Biochemistry

A variant of high-pressure liquid chromatography in which particles as the stationary phase have pores large enough (6000–8000 Ã (600–800 nm)) to permit solvent flow-through and thus allow much ...

Yin-Yang hypothesis

Biology; Biochemistry

The now-abandoned theory that bidirectional cellular processes, i.e. those that involve two individual pathways (rather than one that may be 'on' or 'off'), e.g. proliferation/ contact inhibition, ...

Non-collagen collagen

Biology; Biochemistry

A protein complex that, like collagen, has (Xaa-Yaa-Gly) n amino acid sequences and non-helical globular regions. The collagen-like sequences assemble together into a triple helix and the globular ...

Specificity constant (kcat/Km)

Biology; Biochemistry

The apparent second-order rate constant for enzyme action under conditions where an enzyme's binding site is largely unoccupied by substrate ((S)≪K m ); equivalent to the slope of the (pseudo) ...