Molecular biology

Molecular biology

Contributors in Molecular biology

Molecular biology

The use of pulses of X-rays from a synchrotron to generate hydroxyl radicals, which will quickly react with, and thus label exposed residues of, a macromolecule as time intervals as short as 10 msec. ...

Beta (β)-pleated sheet

Biology; Biochemistry

A form of secondary structure of a protein in which the amide hydrogens of a peptide bond of one extended polypeptide sequence are shared with the carbonyl oxygens of a peptide bond on a second ...

Flux-generating step

Biology; Biochemistry

An enzymic reaction that limits the rate of subsequent steps in its metabolic pathway. In a steady state the flux of metabolites, expressed as mmol/min, is the same for all steps. The step is usually ...

Crossover experiment

Biology; Biochemistry

A method to detect the control point in a metabolic pathway by observation of the effect on metabolite levels as new steady-state levels are established after sudden creation or relieving of an ...

Saturation

Biology; Biochemistry

In protein chemistry, the limit at which a reversible binding site is fully occupied by a ligand. In magnetic resonance, saturation is the raising of a paramagnetic compound or chemical group to an ...

NIH shift

Biology; Biochemistry

The mechanism of a step in the catabolism of tyrosine, named for the National Institutes of Health, where it was described. The sequence of events by which p-hydroxyphenylpyruvate hydroxylase forms ...

Gene duplication

Biology; Biochemistry

The inherited appearance of multiple copies of a gene. Duplication may result in identical or defective copies, either as tandem repeats at the original chromosomal locus, at a neighbouring locus or ...