Biochemistry

Biochemistry

The scientific study of the chemistry of living matter.

Contributors in Biochemistry

Biochemistry

In protein chemistry, the limit at which a reversible binding site is fully occupied by a ligand. In magnetic resonance, saturation is the raising of a paramagnetic compound or chemical group to an ...

NIH shift

Biology; Biochemistry

The mechanism of a step in the catabolism of tyrosine, named for the National Institutes of Health, where it was described. The sequence of events by which p-hydroxyphenylpyruvate hydroxylase forms ...

Gene duplication

Biology; Biochemistry

The inherited appearance of multiple copies of a gene. Duplication may result in identical or defective copies, either as tandem repeats at the original chromosomal locus, at a neighbouring locus or ...

Standard state

Biology; Biochemistry

For solutions in general, the conditions under which thermodynamic properties of a solute are defined, namely 1M. The properties of the solution are those extrapolated from very dilute solutions. In ...

Difference cloning

Biology; Biochemistry

A group of techniques (e.g. subtractive DNA cloning) designed to isolate DNA sequences that are not shared between two DNA sources, e.g. cDNA clones prepared from different tissues, or under ...

Structure-activity relationships by mass spectrometry (SAR by MS)

Biology; Biochemistry

An approach to drug discovery. Sites of interaction of several small molecules with a macromolecule, e.g. aminoglycoside antibiotics with rRNA, are simultaneously probed by MS: the addition to each ...

Tricarboxylic acid cycle (TCA cycle)

Biology; Biochemistry

The metabolic pathway in which acetyl-CoA is catalytically oxidised to carbon dioxide, with the concomitant reduction of NAD + and FAD via a series of tricarboxylic (citric, cisaconitic and ...