Molecular biology

Molecular biology

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Molecular biology

Hydroxylamine and osmium tetroxide (HOT) technique (chemical mismatch detection)

Biology; Biochemistry

A method for detection of single base substitutions in DNA fragments. Heteroduplexes of normal DNA and homologous mutant DNA are generated; the presence of C mismatches allows cleavage with ...

Positional candidate approach

Biology; Biochemistry

A strategy for identification and cloning of a new gene; a combination of functional cloning, in which a property of the protein product (e.g. immunogenicity or liganding) is used to scan a cDNA ...

Actin

Biology; Biochemistry

A protein present in eukaryotic cells, forming actin filaments, which is a major component of the cell's cytoskeleton, the network of relatively rigid structures within a cell that give it shape. ...

A series of blood proteins that contribute to innate immunity. When triggered by a foreign substance or particle, a cascade of enzymatic activations and reactions results in chemotaxis, activation of ...

Fluorescence lifetime

Biology; Biochemistry

The average time that a population of fluorophores spends in the excited state before collapse to the ground state. The lifetime is equal to the reciprocal of the first-order rate constant for the ...

Complementary

Biology; Biochemistry

In nucleic acid chemistry, descriptive of the relationship between two polynucleotides that can combine in an antiparallel double helix; the bases of each polynucleotide are in a hydrogen-bonded ...

Immunoelectrophoresis

Biology; Biochemistry

A method for analysis of antibody or antigen mixtures. A solution of antibodies is electrophoresed in a gel, then exposed to an antigen solution placed in a trough cut into the gel parallel to the ...